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Interactions médicamenteuses

Estradiol + Fezolinetant

Gravité: Contre-indiquée

Estradiol and Fezolinetant: contraindicated interaction.

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Résumé

Estradiol weakly inhibits CYP1A2 and can raise fezolinetant exposure. Higher fezolinetant levels increase the risk of adverse effects including hepatotoxicity, and labeling contraindicates CYP1A2 inhibitors.

Ce que signifie cette interaction, en termes simples

Estradiol and Fezolinetant are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Estradiol belongs to Endocrine; Fezolinetant belongs to Endocrine.

Niveau de preuve: High

Pourquoi elle survient

Estrogens inhibit CYP1A2, the main enzyme metabolizing fezolinetant.

Conduite à tenir

Do not use fezolinetant with estrogen therapy; choose one treatment for vasomotor symptoms. If used, monitor liver tests.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Estradiol with Fezolinetant?

MediHelp rates the interaction as contraindicated. Estradiol and Fezolinetant are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Estradiol weakly inhibits CYP1A2 and can raise fezolinetant exposure. Higher fezolinetant levels increase the risk of adverse effects including hepatotoxicity, and labeling contraindicates CYP1A2 inhibitors.

How serious is the interaction between Estradiol and Fezolinetant?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use fezolinetant with estrogen therapy; choose one treatment for vasomotor symptoms. If used, monitor liver tests.

What other medicines interact with Estradiol?

MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Ospemifene, Antithrombin alfa. The full list is on the Estradiol page.

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