Interactions médicamenteuses
Ethinyl estradiol-drospirenone + Fezolinetant
Gravité: Contre-indiquée
Ethinyl estradiol-drospirenone and Fezolinetant: contraindicated interaction.
Dernière mise à jour
Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.
Le contenu clinique de cette page n'est disponible qu'en anglais.
Résumé
Fezolinetant is metabolized mainly by CYP1A2, and ethinyl estradiol is a weak CYP1A2 inhibitor that can raise fezolinetant exposure. Fezolinetant labeling contraindicates use with CYP1A2 inhibitors, and its indication for menopausal vasomotor symptoms means combined contraceptive use is rarely appropriate anyway. Increased exposure raises the risk of hepatotoxicity.
Ce que signifie cette interaction, en termes simples
Ethinyl estradiol-drospirenone and Fezolinetant are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ethinyl estradiol-drospirenone belongs to Endocrine; Fezolinetant belongs to Endocrine.
Pourquoi elle survient
Ethinyl estradiol inhibits CYP1A2, reducing fezolinetant metabolism and increasing its plasma concentration.
Conduite à tenir
Avoid coadministration. Use an alternative approach for vasomotor symptoms or contraception, and monitor liver tests if fezolinetant is used.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Réservé aux membres Pro+
Débloquer la page complète
Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Ethinyl estradiol-drospirenone et Fezolinetant, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Essayez Pro+ gratuitement pendant 14 jours sur le web. Sans carte.
Autres interactions de Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contre-indiquée
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contre-indiquée
- Ethinyl estradiol-drospirenone + Tranexamic acid Contre-indiquée
- Aminocaproic acid + Ethinyl estradiol-drospirenone Majeure
- Amobarbital + Ethinyl estradiol-drospirenone Majeure
- Anastrozole + Ethinyl estradiol-drospirenone Majeure
Autres interactions de Fezolinetant
- Cimetidine + Fezolinetant Contre-indiquée
- Ciprofloxacin + Fezolinetant Contre-indiquée
- Desogestrel-ethinyl estradiol + Fezolinetant Contre-indiquée
- Estradiol + Fezolinetant Contre-indiquée
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contre-indiquée
- Ethinyl estradiol-norgestimate + Fezolinetant Contre-indiquée
Questions fréquentes
Can I take Ethinyl estradiol-drospirenone with Fezolinetant?
MediHelp rates the interaction as contraindicated. Ethinyl estradiol-drospirenone and Fezolinetant are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fezolinetant is metabolized mainly by CYP1A2, and ethinyl estradiol is a weak CYP1A2 inhibitor that can raise fezolinetant exposure. Fezolinetant labeling contraindicates use with CYP1A2 inhibitors, and its indication for menopausal vasomotor symptoms means combined contraceptive use is rarely appropriate anyway. Increased exposure raises the risk of hepatotoxicity.
How serious is the interaction between Ethinyl estradiol-drospirenone and Fezolinetant?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration. Use an alternative approach for vasomotor symptoms or contraception, and monitor liver tests if fezolinetant is used.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-drospirenone page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
