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Interactions médicamenteuses

Ethinyl estradiol-drospirenone + Tranexamic acid

Gravité: Contre-indiquée

Ethinyl estradiol-drospirenone and Tranexamic acid: contraindicated interaction.

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Résumé

Combined hormonal contraceptives raise the risk of venous thromboembolism and tranexamic acid is antifibrinolytic, so together the thrombotic risk is increased. Oral tranexamic acid labeling contraindicates its use with combined hormonal contraception.

Ce que signifie cette interaction, en termes simples

Ethinyl estradiol-drospirenone and Tranexamic acid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Ethinyl estradiol-drospirenone belongs to Endocrine; Tranexamic acid belongs to Cardiovascular.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive prothrombotic effects from estrogen-induced coagulation changes and antifibrinolysis.

Conduite à tenir

Avoid coadministration; for heavy menstrual bleeding consider a non-hormonal or progestin-only alternative, or an alternative to tranexamic acid.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Ethinyl estradiol-drospirenone with Tranexamic acid?

MediHelp rates the interaction as contraindicated. Ethinyl estradiol-drospirenone and Tranexamic acid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combined hormonal contraceptives raise the risk of venous thromboembolism and tranexamic acid is antifibrinolytic, so together the thrombotic risk is increased. Oral tranexamic acid labeling contraindicates its use with combined hormonal contraception.

How serious is the interaction between Ethinyl estradiol-drospirenone and Tranexamic acid?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration; for heavy menstrual bleeding consider a non-hormonal or progestin-only alternative, or an alternative to tranexamic acid.

What other medicines interact with Ethinyl estradiol-drospirenone?

MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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