Interactions médicamenteuses
Ethinyl estradiol-levonorgestrel + Exemestane
Gravité: Majeure
Ethinyl estradiol-levonorgestrel and Exemestane: major interaction.
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Résumé
Exemestane is an aromatase inactivator used to lower estrogen in postmenopausal women with breast cancer. Giving an estrogen-containing contraceptive works against its purpose, and the combination is not appropriate. The patient is also unlikely to need a contraceptive in this setting.
Ce que signifie cette interaction, en termes simples
Ethinyl estradiol-levonorgestrel and Exemestane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ethinyl estradiol-levonorgestrel belongs to Endocrine; Exemestane belongs to Oncology.
Pourquoi elle survient
Exogenous estrogen opposes the estrogen-lowering pharmacodynamic effect of exemestane.
Conduite à tenir
Avoid estrogen-containing products with exemestane. Use non-hormonal approaches if contraception or symptom control is needed.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Ethinyl estradiol-levonorgestrel
- Ethinyl estradiol-levonorgestrel + Fezolinetant Contre-indiquée
- Ethinyl estradiol-levonorgestrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contre-indiquée
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contre-indiquée
- Aminocaproic acid + Ethinyl estradiol-levonorgestrel Majeure
- Amobarbital + Ethinyl estradiol-levonorgestrel Majeure
- Anastrozole + Ethinyl estradiol-levonorgestrel Majeure
Autres interactions de Exemestane
Questions fréquentes
Can I take Ethinyl estradiol-levonorgestrel with Exemestane?
MediHelp rates the interaction as major. Ethinyl estradiol-levonorgestrel and Exemestane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Exemestane is an aromatase inactivator used to lower estrogen in postmenopausal women with breast cancer. Giving an estrogen-containing contraceptive works against its purpose, and the combination is not appropriate. The patient is also unlikely to need a contraceptive in this setting.
How serious is the interaction between Ethinyl estradiol-levonorgestrel and Exemestane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid estrogen-containing products with exemestane. Use non-hormonal approaches if contraception or symptom control is needed.
What other medicines interact with Ethinyl estradiol-levonorgestrel?
MediHelp also lists interactions of Ethinyl estradiol-levonorgestrel with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-levonorgestrel page.
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