Interactions médicamenteuses
Fexinidazole + Tinidazole
Gravité: Majeure
Fexinidazole and Tinidazole: major interaction.
Dernière mise à jour
Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.
Le contenu clinique de cette page n'est disponible qu'en anglais.
Résumé
Both are nitroimidazoles, and fexinidazole can inhibit CYP3A4, but tinidazole is only partly CYP3A4-dependent. Fexinidazole also carries QT-prolonging risk and neuropsychiatric effects, and combining two nitroimidazoles offers no therapeutic benefit and adds to toxicity.
Ce que signifie cette interaction, en termes simples
Fexinidazole and Tinidazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Possible CYP3A4 inhibition by fexinidazole raising tinidazole levels, with overlapping nitroimidazole toxicity.
Conduite à tenir
Avoid using the two together. If unavoidable, monitor ECG and neuropsychiatric status.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Réservé aux membres Pro+
Débloquer la page complète
Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Fexinidazole et Tinidazole, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Essayez Pro+ gratuitement pendant 14 jours sur le web. Sans carte.
Autres interactions de Tinidazole
- Disulfiram + Tinidazole Contre-indiquée
- Ethanol + Tinidazole Majeure
- Lopinavir + Tinidazole Majeure
- Nilotinib + Tinidazole Majeure
- Ritonavir + Tinidazole Majeure
- Amiodarone + Tinidazole Modérée
Questions fréquentes
Can I take Fexinidazole with Tinidazole?
MediHelp rates the interaction as major. Fexinidazole and Tinidazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are nitroimidazoles, and fexinidazole can inhibit CYP3A4, but tinidazole is only partly CYP3A4-dependent. Fexinidazole also carries QT-prolonging risk and neuropsychiatric effects, and combining two nitroimidazoles offers no therapeutic benefit and adds to toxicity.
How serious is the interaction between Fexinidazole and Tinidazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using the two together. If unavoidable, monitor ECG and neuropsychiatric status.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Lopinavir. The full list is on the Tinidazole page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
