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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Ritonavir + Tinidazole

Gravité: Majeure

Ritonavir and Tinidazole: major interaction.

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Résumé

Ritonavir oral solution contains ethanol, and tinidazole can provoke a disulfiram-like reaction with alcohol, causing flushing, vomiting, tachycardia and headache. The risk is tied to the alcohol-containing liquid formulation rather than ritonavir itself.

Ce que signifie cette interaction, en termes simples

Ritonavir and Tinidazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Ritonavir belongs to Anti Virals; Tinidazole belongs to Anti Parasitic.

Niveau de preuve: Moderate

Pourquoi elle survient

Ethanol in the ritonavir oral solution combined with tinidazole's disulfiram-like inhibition of alcohol metabolism.

Conduite à tenir

Avoid ritonavir oral solution during tinidazole treatment and for 3 days after; use ritonavir tablets or another formulation if coadministration is needed.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Ritonavir with Tinidazole?

MediHelp rates the interaction as major. Ritonavir and Tinidazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ritonavir oral solution contains ethanol, and tinidazole can provoke a disulfiram-like reaction with alcohol, causing flushing, vomiting, tachycardia and headache. The risk is tied to the alcohol-containing liquid formulation rather than ritonavir itself.

How serious is the interaction between Ritonavir and Tinidazole?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ritonavir oral solution during tinidazole treatment and for 3 days after; use ritonavir tablets or another formulation if coadministration is needed.

What other medicines interact with Tinidazole?

MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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