Interactions médicamenteuses
Disulfiram + Tinidazole
Gravité: Contre-indiquée
Disulfiram and Tinidazole: contraindicated interaction.
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Résumé
Tinidazole labeling advises against use within two weeks of disulfiram. The combination has been associated with psychotic reactions and confusion, and a disulfiram-like reaction with alcohol is also a concern.
Ce que signifie cette interaction, en termes simples
Disulfiram and Tinidazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Additive central nervous system toxicity; the exact mechanism is not established.
Conduite à tenir
Do not give tinidazole to patients who have taken disulfiram in the past two weeks. Choose an alternative antimicrobial.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Tinidazole
- Ethanol + Tinidazole Majeure
- Fexinidazole + Tinidazole Majeure
- Lopinavir + Tinidazole Majeure
- Nilotinib + Tinidazole Majeure
- Ritonavir + Tinidazole Majeure
- Amiodarone + Tinidazole Modérée
Questions fréquentes
Can I take Disulfiram with Tinidazole?
MediHelp rates the interaction as contraindicated. Disulfiram and Tinidazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tinidazole labeling advises against use within two weeks of disulfiram. The combination has been associated with psychotic reactions and confusion, and a disulfiram-like reaction with alcohol is also a concern.
How serious is the interaction between Disulfiram and Tinidazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give tinidazole to patients who have taken disulfiram in the past two weeks. Choose an alternative antimicrobial.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Ethanol, Fexinidazole, Lopinavir. The full list is on the Tinidazole page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
