Interactions médicamenteuses
Fingolimod + Ponesimod
Gravité: Contre-indiquée
Fingolimod and Ponesimod: contraindicated interaction.
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Résumé
Both are sphingosine-1-phosphate receptor modulators that lower heart rate and reduce circulating lymphocytes. Using them together duplicates therapy and increases the risk of bradyarrhythmia, conduction delay and infection.
Ce que signifie cette interaction, en termes simples
Fingolimod and Ponesimod are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Fingolimod belongs to Central Nervous System; Ponesimod belongs to Central Nervous System.
Pourquoi elle survient
Duplicate S1P receptor modulation producing additive negative chronotropic and immunosuppressive effects.
Conduite à tenir
Do not combine; allow adequate washout of one agent, guided by labeling, before starting the other, with cardiac monitoring at initiation.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Fingolimod
- Adenovirus types 4 and 7 live + Fingolimod Contre-indiquée
- Bcg vaccine live + Fingolimod Contre-indiquée
- Fingolimod + Pimozide Contre-indiquée
- Fingolimod + Quinidine Contre-indiquée
- Fingolimod + Siponimod Contre-indiquée
- Fingolimod + Sotalol Contre-indiquée
Autres interactions de Ponesimod
- Ponesimod + Siponimod Contre-indiquée
- Amiodarone + Ponesimod Majeure
- Amisulpride + Ponesimod Majeure
- Anagrelide + Ponesimod Majeure
- Anti-thymocyte + Ponesimod Majeure
- Asenapine + Ponesimod Majeure
Questions fréquentes
Can I take Fingolimod with Ponesimod?
MediHelp rates the interaction as contraindicated. Fingolimod and Ponesimod are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both are sphingosine-1-phosphate receptor modulators that lower heart rate and reduce circulating lymphocytes. Using them together duplicates therapy and increases the risk of bradyarrhythmia, conduction delay and infection.
How serious is the interaction between Fingolimod and Ponesimod?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; allow adequate washout of one agent, guided by labeling, before starting the other, with cardiac monitoring at initiation.
What other medicines interact with Fingolimod?
MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
