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Interactions médicamenteuses

Fingolimod + Siponimod

Gravité: Contre-indiquée

Fingolimod and Siponimod: contraindicated interaction.

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Résumé

Both drugs are S1P receptor modulators that reduce heart rate and lymphocyte counts. Concurrent use gives duplicated pharmacology with additive bradycardia, conduction effects and immunosuppression.

Ce que signifie cette interaction, en termes simples

Fingolimod and Siponimod are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Fingolimod belongs to Central Nervous System; Siponimod belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Duplicate S1P receptor modulation with additive negative chronotropic and immunosuppressive effects.

Conduite à tenir

Do not use together; allow an adequate washout when switching, with lymphocyte recovery and cardiac monitoring as indicated.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Fingolimod with Siponimod?

MediHelp rates the interaction as contraindicated. Fingolimod and Siponimod are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs are S1P receptor modulators that reduce heart rate and lymphocyte counts. Concurrent use gives duplicated pharmacology with additive bradycardia, conduction effects and immunosuppression.

How serious is the interaction between Fingolimod and Siponimod?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; allow an adequate washout when switching, with lymphocyte recovery and cardiac monitoring as indicated.

What other medicines interact with Fingolimod?

MediHelp also lists interactions of Fingolimod with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Pimozide. The full list is on the Fingolimod page.

Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp

Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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