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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Anti-thymocyte + Ponesimod

Gravité: Majeure

Anti-thymocyte and Ponesimod: major interaction.

Dernière mise à jour

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Résumé

Anti-thymocyte globulin causes profound lymphocyte depletion and ponesimod reduces circulating lymphocytes by sequestration. Combined, they may substantially raise the risk of serious infection, and effects persist after either drug is stopped.

Ce que signifie cette interaction, en termes simples

Anti-thymocyte and Ponesimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Anti-thymocyte belongs to Miscellaneous; Ponesimod belongs to Central Nervous System.

Niveau de preuve: Low

Pourquoi elle survient

Additive immunosuppression via T-cell depletion and S1P receptor modulation.

Conduite à tenir

Avoid starting ponesimod during or soon after anti-thymocyte globulin where possible. If used, monitor lymphocyte counts and infection signs closely.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Anti-thymocyte with Ponesimod?

MediHelp rates the interaction as major. Anti-thymocyte and Ponesimod can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Anti-thymocyte globulin causes profound lymphocyte depletion and ponesimod reduces circulating lymphocytes by sequestration. Combined, they may substantially raise the risk of serious infection, and effects persist after either drug is stopped.

How serious is the interaction between Anti-thymocyte and Ponesimod?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting ponesimod during or soon after anti-thymocyte globulin where possible. If used, monitor lymphocyte counts and infection signs closely.

What other medicines interact with Anti-thymocyte?

MediHelp also lists interactions of Anti-thymocyte with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Anti-thymocyte page.

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