Interactions médicamenteuses
Fluticasone-salmeterol + Fosamprenavir
Gravité: Contre-indiquée
Fluticasone-salmeterol and Fosamprenavir: contraindicated interaction.
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Résumé
Fosamprenavir (as amprenavir, usually ritonavir-boosted) inhibits CYP3A4 and can substantially increase salmeterol exposure. This raises the risk of QT prolongation, tachycardia and arrhythmia. Systemic fluticasone exposure also rises, risking adrenal suppression.
Ce que signifie cette interaction, en termes simples
Fluticasone-salmeterol and Fosamprenavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
CYP3A4 inhibition reduces the metabolism of salmeterol and fluticasone.
Conduite à tenir
Avoid concurrent use and switch to an alternative inhaled corticosteroid/LABA less reliant on CYP3A4, such as beclomethasone-based therapy. Monitor ECG and cortisol-related effects if it cannot be avoided.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Fluticasone-salmeterol
- Darunavir + Fluticasone-salmeterol Contre-indiquée
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Fluticasone-salmeterol Contre-indiquée
- Fluticasone-salmeterol + Indinavir Contre-indiquée
- Fluticasone-salmeterol + Lopinavir Contre-indiquée
- Fluticasone-salmeterol + Nelfinavir Contre-indiquée
- Fluticasone-salmeterol + Ritonavir Contre-indiquée
Questions fréquentes
Can I take Fluticasone-salmeterol with Fosamprenavir?
MediHelp rates the interaction as contraindicated. Fluticasone-salmeterol and Fosamprenavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Fosamprenavir (as amprenavir, usually ritonavir-boosted) inhibits CYP3A4 and can substantially increase salmeterol exposure. This raises the risk of QT prolongation, tachycardia and arrhythmia. Systemic fluticasone exposure also rises, risking adrenal suppression.
How serious is the interaction between Fluticasone-salmeterol and Fosamprenavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and switch to an alternative inhaled corticosteroid/LABA less reliant on CYP3A4, such as beclomethasone-based therapy. Monitor ECG and cortisol-related effects if it cannot be avoided.
What other medicines interact with Fluticasone-salmeterol?
MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Indinavir. The full list is on the Fluticasone-salmeterol page.
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