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Interactions médicamenteuses

Fluticasone-salmeterol + Ritonavir

Gravité: Contre-indiquée

Fluticasone-salmeterol and Ritonavir: contraindicated interaction.

Dernière mise à jour

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Résumé

Ritonavir is a potent CYP3A4 inhibitor that markedly increases salmeterol exposure, leading to QT prolongation, tachycardia and arrhythmias. It also substantially raises systemic fluticasone levels, and cases of Cushing's syndrome and adrenal suppression have been reported.

Ce que signifie cette interaction, en termes simples

Fluticasone-salmeterol and Ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Fluticasone-salmeterol belongs to Respiratory; Ritonavir belongs to Anti Virals.

Niveau de preuve: High

Pourquoi elle survient

Potent CYP3A4 inhibition by ritonavir reduces clearance of salmeterol and fluticasone.

Conduite à tenir

Avoid the combination and use an alternative such as beclomethasone or another non-CYP3A4-dependent regimen. If unavoidable, monitor ECG, potassium and adrenal function.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Fluticasone-salmeterol with Ritonavir?

MediHelp rates the interaction as contraindicated. Fluticasone-salmeterol and Ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ritonavir is a potent CYP3A4 inhibitor that markedly increases salmeterol exposure, leading to QT prolongation, tachycardia and arrhythmias. It also substantially raises systemic fluticasone levels, and cases of Cushing's syndrome and adrenal suppression have been reported.

How serious is the interaction between Fluticasone-salmeterol and Ritonavir?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative such as beclomethasone or another non-CYP3A4-dependent regimen. If unavoidable, monitor ECG, potassium and adrenal function.

What other medicines interact with Fluticasone-salmeterol?

MediHelp also lists interactions of Fluticasone-salmeterol with, for example, Darunavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Fosamprenavir. The full list is on the Fluticasone-salmeterol page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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