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Interactions médicamenteuses

Fluvoxamine + Isocarboxazid

Gravité: Contre-indiquée

Fluvoxamine and Isocarboxazid: contraindicated interaction.

Dernière mise à jour

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Résumé

Isocarboxazid irreversibly inhibits monoamine oxidase, so serotonin is not broken down, and fluvoxamine is an SSRI that increases synaptic serotonin. Together they can precipitate serotonin syndrome with hyperthermia, agitation, clonus and autonomic instability, which can be fatal.

Ce que signifie cette interaction, en termes simples

Fluvoxamine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Fluvoxamine belongs to Central Nervous System; Isocarboxazid belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

Excess serotonergic activity (MAO inhibition plus serotonin reuptake or receptor effects)

Conduite à tenir

Do not co-administer. Leave at least 14 days after stopping isocarboxazid before starting fluvoxamine, and at least 14 days after stopping fluvoxamine before starting isocarboxazid.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Fluvoxamine with Isocarboxazid?

MediHelp rates the interaction as contraindicated. Fluvoxamine and Isocarboxazid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Isocarboxazid irreversibly inhibits monoamine oxidase, so serotonin is not broken down, and fluvoxamine is an SSRI that increases synaptic serotonin. Together they can precipitate serotonin syndrome with hyperthermia, agitation, clonus and autonomic instability, which can be fatal.

How serious is the interaction between Fluvoxamine and Isocarboxazid?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer. Leave at least 14 days after stopping isocarboxazid before starting fluvoxamine, and at least 14 days after stopping fluvoxamine before starting isocarboxazid.

What other medicines interact with Fluvoxamine?

MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.

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