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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Fluvoxamine + Mavacamten

Gravité: Contre-indiquée

Fluvoxamine and Mavacamten: contraindicated interaction.

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Résumé

Mavacamten is metabolised largely by CYP2C19, which fluvoxamine strongly inhibits. Higher exposure can reduce ejection fraction and cause heart failure due to systolic dysfunction.

Ce que signifie cette interaction, en termes simples

Fluvoxamine and Mavacamten are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Fluvoxamine belongs to Central Nervous System; Mavacamten belongs to Cardiovascular.

Niveau de preuve: High

Pourquoi elle survient

Fluvoxamine inhibits CYP2C19 (and CYP3A4) and reduces mavacamten clearance.

Conduite à tenir

Avoid the combination and select another antidepressant. If fluvoxamine is started or stopped in a patient on mavacamten, monitor LVEF and adjust the dose per labeling.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Fluvoxamine with Mavacamten?

MediHelp rates the interaction as contraindicated. Fluvoxamine and Mavacamten are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Mavacamten is metabolised largely by CYP2C19, which fluvoxamine strongly inhibits. Higher exposure can reduce ejection fraction and cause heart failure due to systolic dysfunction.

How serious is the interaction between Fluvoxamine and Mavacamten?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and select another antidepressant. If fluvoxamine is started or stopped in a patient on mavacamten, monitor LVEF and adjust the dose per labeling.

What other medicines interact with Fluvoxamine?

MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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