Interactions médicamenteuses
Gemfibrozil + Glimepiride-pioglitazone
Gravité: Majeure
Gemfibrozil and Glimepiride-pioglitazone: major interaction.
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Résumé
Gemfibrozil strongly inhibits CYP2C8, increasing pioglitazone exposure severalfold. This raises the risk of dose-related adverse effects such as edema, weight gain, heart failure and hypoglycemia with glimepiride.
Ce que signifie cette interaction, en termes simples
Gemfibrozil and Glimepiride-pioglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gemfibrozil belongs to Cardiovascular; Glimepiride-pioglitazone belongs to Endocrine.
Pourquoi elle survient
Inhibition of CYP2C8-mediated pioglitazone metabolism by gemfibrozil.
Conduite à tenir
Limit pioglitazone to no more than 15 mg daily with gemfibrozil, per labeling, or use fenofibrate instead. Monitor glucose and for fluid retention.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Glimepiride-pioglitazone
Autres interactions de Gemfibrozil
- Daprodustat + Gemfibrozil Contre-indiquée
- Elagolix + Gemfibrozil Contre-indiquée
- Gemfibrozil + Mavacamten Contre-indiquée
- Gemfibrozil + Metformin-repaglinide Contre-indiquée
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contre-indiquée
- Gemfibrozil + Repaglinide Contre-indiquée
Questions fréquentes
Can I take Gemfibrozil with Glimepiride-pioglitazone?
MediHelp rates the interaction as major. Gemfibrozil and Glimepiride-pioglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gemfibrozil strongly inhibits CYP2C8, increasing pioglitazone exposure severalfold. This raises the risk of dose-related adverse effects such as edema, weight gain, heart failure and hypoglycemia with glimepiride.
How serious is the interaction between Gemfibrozil and Glimepiride-pioglitazone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit pioglitazone to no more than 15 mg daily with gemfibrozil, per labeling, or use fenofibrate instead. Monitor glucose and for fluid retention.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Insulin aspart, Insulin degludec. The full list is on the Glimepiride-pioglitazone page.
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