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Interactions médicamenteuses

Gemfibrozil + Mavacamten

Gravité: Contre-indiquée

Gemfibrozil and Mavacamten: contraindicated interaction.

Dernière mise à jour

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Résumé

Mavacamten is cleared mainly by CYP2C19 with a contribution from CYP3A4. Gemfibrozil and its glucuronide inhibit several CYP enzymes, so mavacamten exposure may rise. Excess mavacamten can depress left ventricular ejection fraction and cause systolic heart failure.

Ce que signifie cette interaction, en termes simples

Gemfibrozil and Mavacamten are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Gemfibrozil belongs to Cardiovascular; Mavacamten belongs to Cardiovascular.

Niveau de preuve: Low

Pourquoi elle survient

Inhibition of CYP2C19-mediated metabolism of mavacamten increases its systemic exposure.

Conduite à tenir

Avoid the combination and use an alternative lipid-lowering agent. If treatment cannot be changed, monitor echocardiographic LVEF closely and adjust the mavacamten dose per labeling.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Gemfibrozil with Mavacamten?

MediHelp rates the interaction as contraindicated. Gemfibrozil and Mavacamten are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Mavacamten is cleared mainly by CYP2C19 with a contribution from CYP3A4. Gemfibrozil and its glucuronide inhibit several CYP enzymes, so mavacamten exposure may rise. Excess mavacamten can depress left ventricular ejection fraction and cause systolic heart failure.

How serious is the interaction between Gemfibrozil and Mavacamten?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative lipid-lowering agent. If treatment cannot be changed, monitor echocardiographic LVEF closely and adjust the mavacamten dose per labeling.

What other medicines interact with Gemfibrozil?

MediHelp also lists interactions of Gemfibrozil with, for example, Daprodustat, Elagolix, Metformin-repaglinide. The full list is on the Gemfibrozil page.

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