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Interactions médicamenteuses

Elagolix + Gemfibrozil

Gravité: Contre-indiquée

Elagolix and Gemfibrozil: contraindicated interaction.

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Résumé

Gemfibrozil raises elagolix plasma concentrations substantially. Higher elagolix exposure increases the risk of dose-related adverse effects such as bone mineral density loss, hepatic transaminase elevation and mood changes. Labeling lists strong OATP1B1 inhibitors as contraindicated.

Ce que signifie cette interaction, en termes simples

Elagolix and Gemfibrozil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Elagolix belongs to Musculoskeletal; Gemfibrozil belongs to Cardiovascular.

Niveau de preuve: High

Pourquoi elle survient

Gemfibrozil inhibits hepatic OATP1B1 uptake of elagolix, reducing its hepatic clearance and increasing systemic exposure.

Conduite à tenir

Do not co-administer elagolix with gemfibrozil. Choose a different lipid-lowering agent such as a statin or fenofibrate, or an alternative therapy for endometriosis.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Elagolix with Gemfibrozil?

MediHelp rates the interaction as contraindicated. Elagolix and Gemfibrozil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Gemfibrozil raises elagolix plasma concentrations substantially. Higher elagolix exposure increases the risk of dose-related adverse effects such as bone mineral density loss, hepatic transaminase elevation and mood changes. Labeling lists strong OATP1B1 inhibitors as contraindicated.

How serious is the interaction between Elagolix and Gemfibrozil?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer elagolix with gemfibrozil. Choose a different lipid-lowering agent such as a statin or fenofibrate, or an alternative therapy for endometriosis.

What other medicines interact with Gemfibrozil?

MediHelp also lists interactions of Gemfibrozil with, for example, Daprodustat, Mavacamten, Metformin-repaglinide. The full list is on the Gemfibrozil page.

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