Interactions médicamenteuses
Gemfibrozil + Iptacopan
Gravité: Modérée
Gemfibrozil and Iptacopan: moderate interaction.
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Résumé
Iptacopan is partly metabolized by CYP2C8, and gemfibrozil is a strong CYP2C8 inhibitor. The interaction may increase iptacopan exposure, although the clinical consequence is uncertain.
Ce que signifie cette interaction, en termes simples
Gemfibrozil and Iptacopan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Gemfibrozil belongs to Cardiovascular; Iptacopan belongs to Miscellaneous.
Pourquoi elle survient
Gemfibrozil and its glucuronide inhibit CYP2C8, decreasing iptacopan metabolism.
Conduite à tenir
Monitor for iptacopan adverse effects such as headache and infection, including encapsulated bacterial infection. Consider an alternative lipid-lowering drug if exposure concerns arise.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Gemfibrozil
- Daprodustat + Gemfibrozil Contre-indiquée
- Elagolix + Gemfibrozil Contre-indiquée
- Gemfibrozil + Mavacamten Contre-indiquée
- Gemfibrozil + Metformin-repaglinide Contre-indiquée
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contre-indiquée
- Gemfibrozil + Repaglinide Contre-indiquée
Autres interactions de Iptacopan
- Carbamazepine + Iptacopan Modérée
- Iptacopan + Phenytoin Modérée
- Iptacopan + Rifampicin Modérée
- Iptacopan + Secobarbital Modérée
Questions fréquentes
Can I take Gemfibrozil with Iptacopan?
MediHelp rates the interaction as moderate. Gemfibrozil and Iptacopan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iptacopan is partly metabolized by CYP2C8, and gemfibrozil is a strong CYP2C8 inhibitor. The interaction may increase iptacopan exposure, although the clinical consequence is uncertain.
How serious is the interaction between Gemfibrozil and Iptacopan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for iptacopan adverse effects such as headache and infection, including encapsulated bacterial infection. Consider an alternative lipid-lowering drug if exposure concerns arise.
What other medicines interact with Gemfibrozil?
MediHelp also lists interactions of Gemfibrozil with, for example, Daprodustat, Elagolix, Mavacamten. The full list is on the Gemfibrozil page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
