Interactions médicamenteuses
Gemfibrozil + Metformin-pioglitazone
Gravité: Majeure
Gemfibrozil and Metformin-pioglitazone: major interaction.
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Résumé
Gemfibrozil substantially increases pioglitazone exposure by inhibiting its metabolism. This raises the risk of dose-related adverse effects such as edema, weight gain, heart failure and hypoglycemia.
Ce que signifie cette interaction, en termes simples
Gemfibrozil and Metformin-pioglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Gemfibrozil belongs to Cardiovascular; Metformin-pioglitazone belongs to Endocrine.
Pourquoi elle survient
Gemfibrozil inhibits CYP2C8, the main enzyme metabolizing pioglitazone.
Conduite à tenir
Limit pioglitazone to a maximum of 15 mg daily with gemfibrozil. Monitor glucose and for edema or heart failure signs.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Metformin-pioglitazone
Autres interactions de Gemfibrozil
- Daprodustat + Gemfibrozil Contre-indiquée
- Elagolix + Gemfibrozil Contre-indiquée
- Gemfibrozil + Mavacamten Contre-indiquée
- Gemfibrozil + Metformin-repaglinide Contre-indiquée
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contre-indiquée
- Gemfibrozil + Repaglinide Contre-indiquée
Questions fréquentes
Can I take Gemfibrozil with Metformin-pioglitazone?
MediHelp rates the interaction as major. Gemfibrozil and Metformin-pioglitazone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gemfibrozil substantially increases pioglitazone exposure by inhibiting its metabolism. This raises the risk of dose-related adverse effects such as edema, weight gain, heart failure and hypoglycemia.
How serious is the interaction between Gemfibrozil and Metformin-pioglitazone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit pioglitazone to a maximum of 15 mg daily with gemfibrozil. Monitor glucose and for edema or heart failure signs.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
