Interactions médicamenteuses
Dexamethasone-neomycin-polymyxin + Glycerol phenylbutyrate
Gravité: Modérée
Dexamethasone-neomycin-polymyxin and Glycerol phenylbutyrate: moderate interaction.
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Résumé
Corticosteroids promote protein catabolism and may raise plasma ammonia, opposing the ammonia-lowering effect of glycerol phenylbutyrate in urea cycle disorders. This could precipitate hyperammonemia, which is dangerous.
Ce que signifie cette interaction, en termes simples
Dexamethasone-neomycin-polymyxin and Glycerol phenylbutyrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Glycerol phenylbutyrate belongs to Miscellaneous.
Pourquoi elle survient
Corticosteroid-induced protein catabolism increases ammonia production, counteracting the nitrogen-scavenging effect.
Conduite à tenir
Monitor plasma ammonia closely when systemic dexamethasone is used. Adjust the glycerol phenylbutyrate dose as needed.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Majeure
- Dexamethasone-neomycin-polymyxin + Lapatinib Majeure
- Dexamethasone-neomycin-polymyxin + Levofloxacin Majeure
- Dexamethasone-neomycin-polymyxin + Mifepristone Majeure
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Majeure
- Aldesleukin + Dexamethasone-neomycin-polymyxin Modérée
Autres interactions de Glycerol phenylbutyrate
Questions fréquentes
Can I take Dexamethasone-neomycin-polymyxin with Glycerol phenylbutyrate?
MediHelp rates the interaction as moderate. Dexamethasone-neomycin-polymyxin and Glycerol phenylbutyrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids promote protein catabolism and may raise plasma ammonia, opposing the ammonia-lowering effect of glycerol phenylbutyrate in urea cycle disorders. This could precipitate hyperammonemia, which is dangerous.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Glycerol phenylbutyrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor plasma ammonia closely when systemic dexamethasone is used. Adjust the glycerol phenylbutyrate dose as needed.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
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