Interactions médicamenteuses
Dexamethasone-tobramycin + Glycerol phenylbutyrate
Gravité: Modérée
Dexamethasone-tobramycin and Glycerol phenylbutyrate: moderate interaction.
Dernière mise à jour
Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.
Le contenu clinique de cette page n'est disponible qu'en anglais.
Résumé
Corticosteroids promote protein catabolism and can raise plasma ammonia, opposing the ammonia-lowering effect of glycerol phenylbutyrate in urea cycle disorders. The concern is mainly with systemic dexamethasone.
Ce que signifie cette interaction, en termes simples
Dexamethasone-tobramycin and Glycerol phenylbutyrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dexamethasone-tobramycin belongs to Anti Bacterial; Glycerol phenylbutyrate belongs to Miscellaneous.
Pourquoi elle survient
Corticosteroid-induced protein breakdown increases nitrogen load and ammonia.
Conduite à tenir
Monitor plasma ammonia closely if systemic corticosteroids are used and adjust the phenylbutyrate dose as needed.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Réservé aux membres Pro+
Débloquer la page complète
Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Dexamethasone-tobramycin et Glycerol phenylbutyrate, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Essayez Pro+ gratuitement pendant 14 jours sur le web. Sans carte.
Autres interactions de Dexamethasone-tobramycin
Autres interactions de Glycerol phenylbutyrate
- Dexamethasone + Glycerol phenylbutyrate Majeure
- Glycerol phenylbutyrate + Sodium valproate Majeure
- Glycerol phenylbutyrate + Valproic acid Majeure
- Cyclosporin + Glycerol phenylbutyrate Modérée
- Dexamethasone-neomycin-polymyxin + Glycerol phenylbutyrate Modérée
- Fludrocortisone + Glycerol phenylbutyrate Modérée
Questions fréquentes
Can I take Dexamethasone-tobramycin with Glycerol phenylbutyrate?
MediHelp rates the interaction as moderate. Dexamethasone-tobramycin and Glycerol phenylbutyrate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids promote protein catabolism and can raise plasma ammonia, opposing the ammonia-lowering effect of glycerol phenylbutyrate in urea cycle disorders. The concern is mainly with systemic dexamethasone.
How serious is the interaction between Dexamethasone-tobramycin and Glycerol phenylbutyrate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor plasma ammonia closely if systemic corticosteroids are used and adjust the phenylbutyrate dose as needed.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
