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Interactions médicamenteuses

Hydroxyurea + Stavudine

Gravité: Majeure

Hydroxyurea and Stavudine: major interaction.

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Résumé

In HIV patients, hydroxyurea combined with stavudine has been associated with pancreatitis, hepatotoxicity and peripheral neuropathy, sometimes fatal. The overlapping toxicities make the combination hazardous.

Ce que signifie cette interaction, en termes simples

Hydroxyurea and Stavudine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Hydroxyurea belongs to Miscellaneous; Stavudine belongs to Anti Virals.

Niveau de preuve: Moderate

Pourquoi elle survient

Overlapping pancreatic, hepatic and neurotoxic effects; the precise mechanism is not fully established.

Conduite à tenir

Avoid the combination and choose an antiretroviral without these overlapping toxicities. If it was used, stop and evaluate promptly for pancreatitis, liver injury or neuropathy.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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  • Evidence detail
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Questions fréquentes

Can I take Hydroxyurea with Stavudine?

MediHelp rates the interaction as major. Hydroxyurea and Stavudine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. In HIV patients, hydroxyurea combined with stavudine has been associated with pancreatitis, hepatotoxicity and peripheral neuropathy, sometimes fatal. The overlapping toxicities make the combination hazardous.

How serious is the interaction between Hydroxyurea and Stavudine?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose an antiretroviral without these overlapping toxicities. If it was used, stop and evaluate promptly for pancreatitis, liver injury or neuropathy.

What other medicines interact with Stavudine?

MediHelp also lists interactions of Stavudine with, for example, Didanosine, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Hydroxycarbamide. The full list is on the Stavudine page.

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