Interactions médicamenteuses
Influenza virus vaccine quadrivalent intranasal + Tacrolimus
Gravité: Contre-indiquée
Influenza virus vaccine quadrivalent intranasal and Tacrolimus: contraindicated interaction.
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Résumé
The intranasal influenza vaccine contains live attenuated virus, which can replicate in immunosuppressed patients on tacrolimus and cause vaccine-strain infection. The immune response may also be reduced.
Ce que signifie cette interaction, en termes simples
Influenza virus vaccine quadrivalent intranasal and Tacrolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Calcineurin inhibition impairs control of live attenuated virus replication.
Conduite à tenir
Do not use the live intranasal vaccine in patients on tacrolimus. Give an inactivated injectable influenza vaccine instead.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contre-indiquée
- Bcg vaccine live + Tacrolimus Contre-indiquée
- Cidofovir + Tacrolimus Contre-indiquée
- Cyclosporin + Tacrolimus Contre-indiquée
- Measles mumps and rubella vaccine live + Tacrolimus Contre-indiquée
- Measles mumps and rubella vaccine + Tacrolimus Contre-indiquée
Questions fréquentes
Can I take Influenza virus vaccine quadrivalent intranasal with Tacrolimus?
MediHelp rates the interaction as contraindicated. Influenza virus vaccine quadrivalent intranasal and Tacrolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The intranasal influenza vaccine contains live attenuated virus, which can replicate in immunosuppressed patients on tacrolimus and cause vaccine-strain infection. The immune response may also be reduced.
How serious is the interaction between Influenza virus vaccine quadrivalent intranasal and Tacrolimus?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use the live intranasal vaccine in patients on tacrolimus. Give an inactivated injectable influenza vaccine instead.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
