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Interactions médicamenteuses

Cyclosporin + Tacrolimus

Gravité: Contre-indiquée

Cyclosporin and Tacrolimus: contraindicated interaction.

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Résumé

Both are calcineurin inhibitors and together they increase nephrotoxicity, neurotoxicity and over-immunosuppression. Cyclosporine can also raise tacrolimus levels, and the two should not be given together.

Ce que signifie cette interaction, en termes simples

Cyclosporin and Tacrolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Cyclosporin belongs to Miscellaneous; Tacrolimus belongs to Miscellaneous.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive calcineurin inhibition and toxicity, with competition for CYP3A4 and P-glycoprotein altering exposure of either drug.

Conduite à tenir

Do not combine the two. When switching, stop one and wait at least 24 hours before starting the other, guided by drug levels and renal function.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cyclosporin with Tacrolimus?

MediHelp rates the interaction as contraindicated. Cyclosporin and Tacrolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both are calcineurin inhibitors and together they increase nephrotoxicity, neurotoxicity and over-immunosuppression. Cyclosporine can also raise tacrolimus levels, and the two should not be given together.

How serious is the interaction between Cyclosporin and Tacrolimus?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine the two. When switching, stop one and wait at least 24 hours before starting the other, guided by drug levels and renal function.

What other medicines interact with Cyclosporin?

MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.

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