Drug interactions
Influenza virus vaccine quadrivalent intranasal + Tacrolimus
Severity: Contraindicated
Influenza virus vaccine quadrivalent intranasal and Tacrolimus: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The intranasal influenza vaccine contains live attenuated virus, which can replicate in immunosuppressed patients on tacrolimus and cause vaccine-strain infection. The immune response may also be reduced.
What this interaction means in plain words
Influenza virus vaccine quadrivalent intranasal and Tacrolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Calcineurin inhibition impairs control of live attenuated virus replication.
What to do
Do not use the live intranasal vaccine in patients on tacrolimus. Give an inactivated injectable influenza vaccine instead.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine + Tacrolimus Contraindicated
Frequently asked questions
Can I take Influenza virus vaccine quadrivalent intranasal with Tacrolimus?
MediHelp rates the interaction as contraindicated. Influenza virus vaccine quadrivalent intranasal and Tacrolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The intranasal influenza vaccine contains live attenuated virus, which can replicate in immunosuppressed patients on tacrolimus and cause vaccine-strain infection. The immune response may also be reduced.
How serious is the interaction between Influenza virus vaccine quadrivalent intranasal and Tacrolimus?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use the live intranasal vaccine in patients on tacrolimus. Give an inactivated injectable influenza vaccine instead.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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