Interactions médicamenteuses
Measles mumps and rubella vaccine live + Tacrolimus
Gravité: Contre-indiquée
Measles mumps and rubella vaccine live and Tacrolimus: contraindicated interaction.
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Résumé
The MMR vaccine contains live attenuated viruses. In tacrolimus-treated patients these viruses may replicate unchecked and cause vaccine-strain disease, and the immune response is likely to be poor.
Ce que signifie cette interaction, en termes simples
Measles mumps and rubella vaccine live and Tacrolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Calcineurin inhibition suppresses cellular immunity, permitting replication of live attenuated vaccine viruses.
Conduite à tenir
Do not give MMR vaccine to patients on tacrolimus. Vaccinate before transplant or immunosuppression where possible, and check immunity by serology.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contre-indiquée
- Bcg vaccine live + Tacrolimus Contre-indiquée
- Cidofovir + Tacrolimus Contre-indiquée
- Cyclosporin + Tacrolimus Contre-indiquée
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contre-indiquée
- Measles mumps and rubella vaccine + Tacrolimus Contre-indiquée
Questions fréquentes
Can I take Measles mumps and rubella vaccine live with Tacrolimus?
MediHelp rates the interaction as contraindicated. Measles mumps and rubella vaccine live and Tacrolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The MMR vaccine contains live attenuated viruses. In tacrolimus-treated patients these viruses may replicate unchecked and cause vaccine-strain disease, and the immune response is likely to be poor.
How serious is the interaction between Measles mumps and rubella vaccine live and Tacrolimus?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give MMR vaccine to patients on tacrolimus. Vaccinate before transplant or immunosuppression where possible, and check immunity by serology.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
