Interactions médicamenteuses
Insulin degludec + Pasireotide
Gravité: Majeure
Insulin degludec and Pasireotide: major interaction.
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Résumé
Pasireotide frequently causes hyperglycemia and can markedly worsen glycemic control in diabetic patients. Insulin requirements may increase substantially.
Ce que signifie cette interaction, en termes simples
Insulin degludec and Pasireotide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Insulin degludec belongs to Endocrine; Pasireotide belongs to Endocrine.
Pourquoi elle survient
Pasireotide suppresses insulin and incretin secretion (GLP-1 and GIP), producing hyperglycemia.
Conduite à tenir
Check glucose before starting pasireotide and monitor frequently afterwards. Intensify insulin degludec as needed, and reduce the dose if pasireotide is stopped.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Insulin degludec
Autres interactions de Pasireotide
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Questions fréquentes
Can I take Insulin degludec with Pasireotide?
MediHelp rates the interaction as major. Insulin degludec and Pasireotide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pasireotide frequently causes hyperglycemia and can markedly worsen glycemic control in diabetic patients. Insulin requirements may increase substantially.
How serious is the interaction between Insulin degludec and Pasireotide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check glucose before starting pasireotide and monitor frequently afterwards. Intensify insulin degludec as needed, and reduce the dose if pasireotide is stopped.
What other medicines interact with Insulin degludec?
MediHelp also lists interactions of Insulin degludec with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin degludec page.
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