Interactions médicamenteuses
Interferon beta 1a + Pretomanid
Gravité: Majeure
Interferon beta 1a and Pretomanid: major interaction.
Dernière mise à jour
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Résumé
The pretomanid-containing regimen is associated with hepatotoxicity, and labeling advises avoiding other hepatotoxic agents. Interferon beta can raise transaminases and occasionally cause liver injury. Combining them may increase the risk of liver damage.
Ce que signifie cette interaction, en termes simples
Interferon beta 1a and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Interferon beta 1a belongs to Central Nervous System; Pretomanid belongs to Anti Bacterial.
Pourquoi elle survient
Additive hepatotoxicity from two agents that can each injure the liver.
Conduite à tenir
Avoid concurrent use where possible and defer interferon beta during tuberculosis treatment. If unavoidable, monitor liver function tests regularly and stop the offending drugs if liver injury develops.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Interferon beta 1a
Autres interactions de Pretomanid
- Amiodarone + Pretomanid Majeure
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- Armodafinil + Pretomanid Majeure
- Azathioprine + Pretomanid Majeure
Questions fréquentes
Can I take Interferon beta 1a with Pretomanid?
MediHelp rates the interaction as major. Interferon beta 1a and Pretomanid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The pretomanid-containing regimen is associated with hepatotoxicity, and labeling advises avoiding other hepatotoxic agents. Interferon beta can raise transaminases and occasionally cause liver injury. Combining them may increase the risk of liver damage.
How serious is the interaction between Interferon beta 1a and Pretomanid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible and defer interferon beta during tuberculosis treatment. If unavoidable, monitor liver function tests regularly and stop the offending drugs if liver injury develops.
What other medicines interact with Interferon beta 1a?
MediHelp also lists interactions of Interferon beta 1a with, for example, Deferiprone, Etrasimod, Hydroxyurea. The full list is on the Interferon beta 1a page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
