Interactions médicamenteuses
Interferon beta 1a + Pexidartinib
Gravité: Majeure
Interferon beta 1a and Pexidartinib: major interaction.
Dernière mise à jour
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Résumé
Pexidartinib carries a boxed warning for serious and potentially fatal liver injury. Interferon beta can also raise liver enzymes and occasionally cause hepatic injury. Together, the risk of hepatotoxicity may be increased.
Ce que signifie cette interaction, en termes simples
Interferon beta 1a and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Interferon beta 1a belongs to Central Nervous System; Pexidartinib belongs to Oncology.
Pourquoi elle survient
Additive hepatotoxicity from two agents that can each cause liver injury.
Conduite à tenir
Avoid coadministration where possible. If both are needed, monitor liver tests frequently and stop pexidartinib or interferon if significant liver injury occurs.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Interferon beta 1a
Autres interactions de Pexidartinib
- Allopurinol + Pexidartinib Majeure
- Amiodarone + Pexidartinib Majeure
- Amobarbital + Pexidartinib Majeure
- Amoxicillin-clavulanic acid + Pexidartinib Majeure
- Apalutamide + Pexidartinib Majeure
- Aprepitant + Pexidartinib Majeure
Questions fréquentes
Can I take Interferon beta 1a with Pexidartinib?
MediHelp rates the interaction as major. Interferon beta 1a and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pexidartinib carries a boxed warning for serious and potentially fatal liver injury. Interferon beta can also raise liver enzymes and occasionally cause hepatic injury. Together, the risk of hepatotoxicity may be increased.
How serious is the interaction between Interferon beta 1a and Pexidartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration where possible. If both are needed, monitor liver tests frequently and stop pexidartinib or interferon if significant liver injury occurs.
What other medicines interact with Interferon beta 1a?
MediHelp also lists interactions of Interferon beta 1a with, for example, Deferiprone, Etrasimod, Hydroxyurea. The full list is on the Interferon beta 1a page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
