Référentiel des médicaments
Interferon beta 1a
Interferon beta 1a is a medicine in the class central nervous system. It is used for multiple sclerosis.
- Classe médicamenteuse: Central Nervous System
- Indications: multiple sclerosis
Dernière mise à jour
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L'essentiel
- Classe médicamenteuse
- Central Nervous System
- Code ATC
- L03AB07
- Formes courantes
- injection
- Dosages courants
- 30 mcg/.5 ml, 22 mcg/0.5 ml, 30 mcg
- Interactions connues
- 18 (Majeure: 9 · Modérée: 8 · Mineure: 1)
- Noms commerciaux
- 10
- Pays et marchés
- 3
Indications
Mécanisme d'action
Recombinant interferon; antiviral, antiproliferative, immunoregulatory protein; alters response to surface antigen and may enhance immune cell activities
Posologie adulte habituelle (résumé de la notice)
Avonex: 30 mcg IM qWk, starting with 7.5 mcg IM for first week, to reduce flu-like symptoms; increase by 7.5 mcg/week for next 3 weeks until recommended dose of 30 mcg/week
Grossesse et allaitement
- Grossesse
- Safe Registry and cohort data (over 1000 pregnancies) show no rise in major birth defects; miscarriage data are inconsistent, and high doses caused miscarriage in monkeys. EU label: may be considered in pregnancy if clinically needed. Plan treatment with the MS specialist.
- Allaitement
- Safe Milk levels are negligible and it is poorly absorbed by mouth. EU label: can be used while breastfeeding. LactMed: many breastfed infants without adverse effects; a preferred MS treatment while nursing, and feeds can resume right after an injection.
Effets indésirables signalés
- Headache
- Nausea
- Injection site reactions
- Flu-like syndrome
- Muscle ache
- URT infection
Précautions particulières
- Thyroid function should be monitored periodically If patients have or develop symptoms of thyroid dysfunction (hypo- or hyperthyroidism),
- Seizures have been temporally associated with use of beta interferons in clinical trials and postmarketing safety surveillance
- Cases of thrombotic microangiopathy (TMA), including thrombotic thrombocytopenic purpura and hemolytic uremic syndrome, some fatal, have been reported
Informez votre pharmacien ou votre médecin en cas de grossesse ou d'allaitement, de maladie rénale ou hépatique, d'allergies, ainsi que de tout autre médicament ou complément que vous prenez.
Principales interactions (18)
- Deferiprone + Interferon beta 1a Major
- Etrasimod + Interferon beta 1a Major
- Hydroxyurea + Interferon beta 1a Major
- Idecabtagene vicleucel + Interferon beta 1a Major
- Interferon beta 1a + Lisocabtagene maraleucel Major
- Interferon beta 1a + Pexidartinib Major
- Interferon beta 1a + Pretomanid Major
- Interferon beta 1a + Ropeginterferon alfa 2b Major
- Interferon beta 1a + Tisagenlecleucel Major
- Acalabrutinib + Interferon beta 1a Moderate
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- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- Patient counselling points
- Food interactions
- IV preparation and dilution
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Questions fréquentes
What is Interferon beta 1a used for?
Interferon beta 1a is a medicine in the class central nervous system. It is used for Multiple sclerosis.
What side effects have been reported with Interferon beta 1a?
Headache, Nausea, Injection site reactions, Flu-like syndrome, Muscle ache, URT infection.
Can Interferon beta 1a be taken in pregnancy or while breastfeeding?
Pregnancy: Safe. Registry and cohort data (over 1000 pregnancies) show no rise in major birth defects; miscarriage data are inconsistent, and high doses caused miscarriage in monkeys. EU label: may be considered in pregnancy if clinically needed. Plan treatment with the MS specialist. Breastfeeding: Safe. Milk levels are negligible and it is poorly absorbed by mouth. EU label: can be used while breastfeeding. LactMed: many breastfed infants without adverse effects; a preferred MS treatment while nursing, and feeds can resume right after an injection.
What does Interferon beta 1a interact with?
MediHelp lists 18 known interactions for Interferon beta 1a. Major: 9 · Moderate: 8 · Minor: 1. The most serious include Deferiprone, Etrasimod, Hydroxyurea.
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