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Interactions médicamenteuses

Isocarboxazid + Palonosetron

Gravité: Majeure

Isocarboxazid and Palonosetron: major interaction.

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Résumé

Non-selective MAO inhibitors markedly raise serotonin availability, and adding a 5-HT3 antagonist has been linked to serotonin syndrome in rare reports. Because the MAOI baseline risk is high, the combination warrants more caution.

Ce que signifie cette interaction, en termes simples

Isocarboxazid and Palonosetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Isocarboxazid belongs to Central Nervous System; Palonosetron belongs to Gastrointestinal Tract.

Niveau de preuve: Low

Pourquoi elle survient

Irreversible MAO inhibition increases serotonin, with possible additive serotonergic effects from the antiemetic.

Conduite à tenir

Prefer a non-serotonergic antiemetic where feasible; if used, give the lowest dose and monitor closely for serotonin syndrome. Stop both drugs and treat if it occurs.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Isocarboxazid with Palonosetron?

MediHelp rates the interaction as major. Isocarboxazid and Palonosetron can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Non-selective MAO inhibitors markedly raise serotonin availability, and adding a 5-HT3 antagonist has been linked to serotonin syndrome in rare reports. Because the MAOI baseline risk is high, the combination warrants more caution.

How serious is the interaction between Isocarboxazid and Palonosetron?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-serotonergic antiemetic where feasible; if used, give the lowest dose and monitor closely for serotonin syndrome. Stop both drugs and treat if it occurs.

What other medicines interact with Palonosetron?

MediHelp also lists interactions of Palonosetron with, for example, Apomorphine, Phenelzine, Tranylcypromine. The full list is on the Palonosetron page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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