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Interactions médicamenteuses

Palonosetron + Tranylcypromine

Gravité: Majeure

Palonosetron and Tranylcypromine: major interaction.

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Résumé

Tranylcypromine is an irreversible nonselective MAO inhibitor that markedly raises serotonin availability. Adding a 5-HT3 antagonist such as palonosetron may contribute to serotonin syndrome, though reports for palonosetron are limited.

Ce que signifie cette interaction, en termes simples

Palonosetron and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Palonosetron belongs to Gastrointestinal Tract; Tranylcypromine belongs to Central Nervous System.

Niveau de preuve: Low

Pourquoi elle survient

Additive serotonergic effects on top of irreversible MAO inhibition; the contribution of 5-HT3 antagonists is not firmly established.

Conduite à tenir

Prefer an antiemetic from another class where possible. If palonosetron is needed, monitor closely for serotonin syndrome after administration.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Palonosetron with Tranylcypromine?

MediHelp rates the interaction as major. Palonosetron and Tranylcypromine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tranylcypromine is an irreversible nonselective MAO inhibitor that markedly raises serotonin availability. Adding a 5-HT3 antagonist such as palonosetron may contribute to serotonin syndrome, though reports for palonosetron are limited.

How serious is the interaction between Palonosetron and Tranylcypromine?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an antiemetic from another class where possible. If palonosetron is needed, monitor closely for serotonin syndrome after administration.

What other medicines interact with Palonosetron?

MediHelp also lists interactions of Palonosetron with, for example, Apomorphine, Isocarboxazid, Phenelzine. The full list is on the Palonosetron page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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