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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Cobicistat + Sildenafil

Gravité: Contre-indiquée

Cobicistat and Sildenafil: contraindicated interaction.

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Résumé

Cobicistat is a strong CYP3A inhibitor that substantially increases sildenafil concentrations. This raises the risk of marked hypotension, syncope, visual effects and prolonged erection.

Ce que signifie cette interaction, en termes simples

Cobicistat and Sildenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Cobicistat belongs to Miscellaneous; Sildenafil belongs to Genitourinary.

Niveau de preuve: High

Pourquoi elle survient

Cobicistat inhibits CYP3A4, reducing sildenafil clearance and first-pass metabolism.

Conduite à tenir

Avoid the combination when sildenafil is used chronically for pulmonary arterial hypertension. For erectile dysfunction, limit sildenafil to 25 mg no more than once every 48 hours and monitor blood pressure.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cobicistat with Sildenafil?

MediHelp rates the interaction as contraindicated. Cobicistat and Sildenafil are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cobicistat is a strong CYP3A inhibitor that substantially increases sildenafil concentrations. This raises the risk of marked hypotension, syncope, visual effects and prolonged erection.

How serious is the interaction between Cobicistat and Sildenafil?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when sildenafil is used chronically for pulmonary arterial hypertension. For erectile dysfunction, limit sildenafil to 25 mg no more than once every 48 hours and monitor blood pressure.

What other medicines interact with Sildenafil?

MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Atazanavir, Elvitegravir / cobicistat / emtricitabine / tenofovir df. The full list is on the Sildenafil page.

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