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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Isotretinoin + Lomitapide

Gravité: Majeure

Isotretinoin and Lomitapide: major interaction.

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Résumé

Both drugs can cause liver enzyme elevations and hepatotoxicity. Using them together may increase the risk or severity of liver injury, which is already a boxed concern with lomitapide.

Ce que signifie cette interaction, en termes simples

Isotretinoin and Lomitapide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Isotretinoin belongs to Dermatology; Lomitapide belongs to Cardiovascular.

Niveau de preuve: Low

Pourquoi elle survient

Additive hepatotoxicity from two agents that can independently injure the liver.

Conduite à tenir

Avoid the combination where possible; if it is necessary, monitor ALT, AST and bilirubin more frequently than usual. Interrupt treatment if transaminases rise significantly.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Isotretinoin with Lomitapide?

MediHelp rates the interaction as major. Isotretinoin and Lomitapide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can cause liver enzyme elevations and hepatotoxicity. Using them together may increase the risk or severity of liver injury, which is already a boxed concern with lomitapide.

How serious is the interaction between Isotretinoin and Lomitapide?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if it is necessary, monitor ALT, AST and bilirubin more frequently than usual. Interrupt treatment if transaminases rise significantly.

What other medicines interact with Lomitapide?

MediHelp also lists interactions of Lomitapide with, for example, Aprepitant, Clarithromycin, Crizotinib. The full list is on the Lomitapide page.

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