Interactions médicamenteuses
Levodopa + Phenelzine (nonselective MAOI)
Gravité: Contre-indiquée
Levodopa and Phenelzine (nonselective MAOI): contraindicated interaction.
Dernière mise à jour Sources: US FDA label
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Résumé
Levodopa with a nonselective MAOI such as phenelzine can cause hypertensive crisis because peripheral dopamine and norepinephrine accumulate. Levodopa labeling contraindicates nonselective MAOIs, which must be stopped at least two weeks beforehand. Severe headache, palpitations and dangerously high blood pressure may occur.
Ce que signifie cette interaction, en termes simples
Levodopa and Phenelzine (nonselective MAOI) are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Nonselective MAO inhibition blocks breakdown of dopamine and norepinephrine formed from levodopa, causing excessive catecholamine accumulation and a pressor response.
Conduite à tenir
Do not combine. Stop phenelzine at least 14 days before starting levodopa.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Références
Autres interactions de Levodopa
- Isocarboxazid + Levodopa Contre-indiquée
- Levodopa + Phenelzine Contre-indiquée
- Levodopa + Procarbazine Contre-indiquée
- Levodopa + Tranylcypromine Contre-indiquée
- Amisulpride + Levodopa Majeure
- Chlorpromazine + Levodopa Majeure
Questions fréquentes
Can I take Levodopa with Phenelzine (nonselective MAOI)?
MediHelp rates the interaction as contraindicated. Levodopa and Phenelzine (nonselective MAOI) are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levodopa with a nonselective MAOI such as phenelzine can cause hypertensive crisis because peripheral dopamine and norepinephrine accumulate. Levodopa labeling contraindicates nonselective MAOIs, which must be stopped at least two weeks beforehand. Severe headache, palpitations and dangerously high blood pressure may occur.
How serious is the interaction between Levodopa and Phenelzine (nonselective MAOI)?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Stop phenelzine at least 14 days before starting levodopa.
What other medicines interact with Levodopa?
MediHelp also lists interactions of Levodopa with, for example, Isocarboxazid, Phenelzine, Procarbazine. The full list is on the Levodopa page.
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