Interactions médicamenteuses
Levodopa + Tranylcypromine
Gravité: Contre-indiquée
Levodopa and Tranylcypromine: contraindicated interaction.
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Résumé
Levodopa is converted to dopamine and norepinephrine, and nonselective MAO inhibition prevents their breakdown. This can produce hypertensive crisis with severe headache and cardiovascular events.
Ce que signifie cette interaction, en termes simples
Levodopa and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Levodopa belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.
Pourquoi elle survient
Increased catecholamine formation with blocked MAO-A and MAO-B degradation causes exaggerated pressor effects.
Conduite à tenir
Avoid the combination and stop the nonselective MAOI at least 14 days before starting levodopa. Selective MAO-B inhibitors are used in Parkinson disease under guidance.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Tranylcypromine
- 5-HTP + Tranylcypromine Contre-indiquée
- Amitriptyline + Tranylcypromine Contre-indiquée
- Amoxapine + Tranylcypromine Contre-indiquée
- Atomoxetine + Tranylcypromine Contre-indiquée
- Benzphetamine + Tranylcypromine Contre-indiquée
- Brimonidine + Tranylcypromine Contre-indiquée
Autres interactions de Levodopa
- Isocarboxazid + Levodopa Contre-indiquée
- Levodopa + Phenelzine Contre-indiquée
- Levodopa + Phenelzine (nonselective MAOI) Contre-indiquée
- Levodopa + Procarbazine Contre-indiquée
- Amisulpride + Levodopa Majeure
- Chlorpromazine + Levodopa Majeure
Questions fréquentes
Can I take Levodopa with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Levodopa and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levodopa is converted to dopamine and norepinephrine, and nonselective MAO inhibition prevents their breakdown. This can produce hypertensive crisis with severe headache and cardiovascular events.
How serious is the interaction between Levodopa and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and stop the nonselective MAOI at least 14 days before starting levodopa. Selective MAO-B inhibitors are used in Parkinson disease under guidance.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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