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Interactions médicamenteuses

Isocarboxazid + Levodopa

Gravité: Contre-indiquée

Isocarboxazid and Levodopa: contraindicated interaction.

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Résumé

Levodopa with a nonselective MAOI can cause hypertensive crisis. Dopamine and norepinephrine formed from levodopa are not metabolized normally.

Ce que signifie cette interaction, en termes simples

Isocarboxazid and Levodopa are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Isocarboxazid belongs to Central Nervous System; Levodopa belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

Nonselective MAO inhibition prevents breakdown of dopamine and norepinephrine formed from levodopa, producing excessive adrenergic stimulation.

Conduite à tenir

Avoid the combination and stop the nonselective MAOI at least 2 weeks before starting levodopa. Selective MAO-B inhibitors are the acceptable alternative in Parkinson disease.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Isocarboxazid with Levodopa?

MediHelp rates the interaction as contraindicated. Isocarboxazid and Levodopa are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Levodopa with a nonselective MAOI can cause hypertensive crisis. Dopamine and norepinephrine formed from levodopa are not metabolized normally.

How serious is the interaction between Isocarboxazid and Levodopa?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and stop the nonselective MAOI at least 2 weeks before starting levodopa. Selective MAO-B inhibitors are the acceptable alternative in Parkinson disease.

What other medicines interact with Isocarboxazid?

MediHelp also lists interactions of Isocarboxazid with, for example, 5-HTP, Amitriptyline, Amobarbital. The full list is on the Isocarboxazid page.

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