Interactions médicamenteuses
Lorlatinib + Primidone
Gravité: Contre-indiquée
Lorlatinib and Primidone: contraindicated interaction.
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Résumé
Primidone is metabolized to phenobarbital and acts as a strong CYP3A4 inducer, which can lower lorlatinib concentrations and risk treatment failure. Strong inducers are contraindicated with lorlatinib, and hepatotoxicity has been seen with this type of combination.
Ce que signifie cette interaction, en termes simples
Lorlatinib and Primidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Lorlatinib belongs to Oncology; Primidone belongs to Central Nervous System.
Pourquoi elle survient
Induction of CYP3A4 by primidone and its phenobarbital metabolite accelerates lorlatinib metabolism.
Conduite à tenir
Do not co-administer; switch to a non-inducing anticonvulsant. Allow washout of about 3 half-lives of the inducer before starting lorlatinib.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Lorlatinib
- Amobarbital + Lorlatinib Contre-indiquée
- Apalutamide + Lorlatinib Contre-indiquée
- Butabarbital + Lorlatinib Contre-indiquée
- Carbamazepine + Lorlatinib Contre-indiquée
- Enzalutamide + Lorlatinib Contre-indiquée
- Fosphenytoin + Lorlatinib Contre-indiquée
Autres interactions de Primidone
- Lurasidone + Primidone Contre-indiquée
- Primidone + Ranolazine Contre-indiquée
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contre-indiquée
- Primidone + Voriconazole Contre-indiquée
- Abiraterone + Primidone Majeure
- Amitriptyline + Primidone Majeure
Questions fréquentes
Can I take Lorlatinib with Primidone?
MediHelp rates the interaction as contraindicated. Lorlatinib and Primidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Primidone is metabolized to phenobarbital and acts as a strong CYP3A4 inducer, which can lower lorlatinib concentrations and risk treatment failure. Strong inducers are contraindicated with lorlatinib, and hepatotoxicity has been seen with this type of combination.
How serious is the interaction between Lorlatinib and Primidone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; switch to a non-inducing anticonvulsant. Allow washout of about 3 half-lives of the inducer before starting lorlatinib.
What other medicines interact with Lorlatinib?
MediHelp also lists interactions of Lorlatinib with, for example, Amobarbital, Apalutamide, Butabarbital. The full list is on the Lorlatinib page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
