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Interactions médicamenteuses

Lurasidone + Primidone

Gravité: Contre-indiquée

Lurasidone and Primidone: contraindicated interaction.

Dernière mise à jour

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Résumé

Primidone is metabolized to phenobarbital, which induces CYP3A4 and may reduce lurasidone concentrations. This can lead to inadequate antipsychotic effect and relapse. Strong CYP3A4 inducers are contraindicated with lurasidone.

Ce que signifie cette interaction, en termes simples

Lurasidone and Primidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Lurasidone belongs to Central Nervous System; Primidone belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Induction of CYP3A4 by primidone and its phenobarbital metabolite increases lurasidone clearance.

Conduite à tenir

Avoid the combination; consider a non-inducing anticonvulsant or an alternative antipsychotic and monitor symptom control.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Lurasidone with Primidone?

MediHelp rates the interaction as contraindicated. Lurasidone and Primidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Primidone is metabolized to phenobarbital, which induces CYP3A4 and may reduce lurasidone concentrations. This can lead to inadequate antipsychotic effect and relapse. Strong CYP3A4 inducers are contraindicated with lurasidone.

How serious is the interaction between Lurasidone and Primidone?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; consider a non-inducing anticonvulsant or an alternative antipsychotic and monitor symptom control.

What other medicines interact with Lurasidone?

MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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