Interactions médicamenteuses
Magnesium hydroxide + Raltegravir
Gravité: Majeure
Magnesium hydroxide and Raltegravir: major interaction.
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Résumé
Magnesium-containing antacids bind raltegravir in the gut and can reduce its plasma concentrations. Lower exposure may risk virologic failure and resistance, particularly with the once-daily 1200 mg regimen.
Ce que signifie cette interaction, en termes simples
Magnesium hydroxide and Raltegravir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Magnesium hydroxide belongs to Gastrointestinal Tract; Raltegravir belongs to Anti Virals.
Pourquoi elle survient
Chelation of raltegravir by magnesium cations in the gastrointestinal tract reduces absorption.
Conduite à tenir
Avoid concomitant use with magnesium-containing antacids; if unavoidable, separate dosing by at least 6 hours. Use a non-cation acid suppressant alternative if possible.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Magnesium hydroxide
Autres interactions de Raltegravir
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Raltegravir Contre-indiquée
- Aluminum hydroxide / magnesium carbonate + Raltegravir Majeure
- Aluminum hydroxide / magnesium trisilicate + Raltegravir Majeure
- Aluminum hydroxide + Raltegravir Majeure
- Atidarsagene autotemcel + Raltegravir Majeure
- Betibeglogene autotemcel + Raltegravir Majeure
Questions fréquentes
Can I take Magnesium hydroxide with Raltegravir?
MediHelp rates the interaction as major. Magnesium hydroxide and Raltegravir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Magnesium-containing antacids bind raltegravir in the gut and can reduce its plasma concentrations. Lower exposure may risk virologic failure and resistance, particularly with the once-daily 1200 mg regimen.
How serious is the interaction between Magnesium hydroxide and Raltegravir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use with magnesium-containing antacids; if unavoidable, separate dosing by at least 6 hours. Use a non-cation acid suppressant alternative if possible.
What other medicines interact with Magnesium hydroxide?
MediHelp also lists interactions of Magnesium hydroxide with, for example, Ciprofloxacin, Dolutegravir, Gemifloxacin. The full list is on the Magnesium hydroxide page.
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