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Interactions médicamenteuses

Measles mumps and rubella vaccine + Sirolimus

Gravité: Contre-indiquée

Measles mumps and rubella vaccine and Sirolimus: contraindicated interaction.

Dernière mise à jour

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Résumé

Sirolimus is a potent immunosuppressant used in transplantation. It may reduce vaccine response and allow the live vaccine viruses to replicate, raising the risk of vaccine-strain infection.

Ce que signifie cette interaction, en termes simples

Measles mumps and rubella vaccine and Sirolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Measles mumps and rubella vaccine belongs to Miscellaneous; Sirolimus belongs to Miscellaneous.

Niveau de preuve: Moderate

Pourquoi elle survient

mTOR inhibition suppresses T-cell proliferation, impairing control of live attenuated virus.

Conduite à tenir

Avoid live vaccines during sirolimus therapy. Give MMR before transplant or immunosuppression where possible.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Measles mumps and rubella vaccine with Sirolimus?

MediHelp rates the interaction as contraindicated. Measles mumps and rubella vaccine and Sirolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sirolimus is a potent immunosuppressant used in transplantation. It may reduce vaccine response and allow the live vaccine viruses to replicate, raising the risk of vaccine-strain infection.

How serious is the interaction between Measles mumps and rubella vaccine and Sirolimus?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live vaccines during sirolimus therapy. Give MMR before transplant or immunosuppression where possible.

What other medicines interact with Measles mumps and rubella vaccine?

MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.

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