Interactions médicamenteuses
Measles mumps and rubella vaccine live + Sirolimus
Gravité: Contre-indiquée
Measles mumps and rubella vaccine live and Sirolimus: contraindicated interaction.
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Résumé
The live MMR vaccine may cause disseminated vaccine-strain infection in patients immunosuppressed with sirolimus, and immunogenicity may be poor.
Ce que signifie cette interaction, en termes simples
Measles mumps and rubella vaccine live and Sirolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Sirolimus immunosuppression permits replication of live attenuated viruses and blunts vaccine response.
Conduite à tenir
Do not administer during sirolimus therapy. Immunize before transplant or immunosuppression, and check immunity serologically.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contre-indiquée
- Bcg vaccine live + Sirolimus Contre-indiquée
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contre-indiquée
- Ketoconazole + Sirolimus Contre-indiquée
- Levoketoconazole + Sirolimus Contre-indiquée
- Measles mumps and rubella vaccine + Sirolimus Contre-indiquée
Questions fréquentes
Can I take Measles mumps and rubella vaccine live with Sirolimus?
MediHelp rates the interaction as contraindicated. Measles mumps and rubella vaccine live and Sirolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The live MMR vaccine may cause disseminated vaccine-strain infection in patients immunosuppressed with sirolimus, and immunogenicity may be poor.
How serious is the interaction between Measles mumps and rubella vaccine live and Sirolimus?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not administer during sirolimus therapy. Immunize before transplant or immunosuppression, and check immunity serologically.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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