Interactions médicamenteuses
Meropenem + Valproic acid
Gravité: Contre-indiquée
Meropenem and Valproic acid: contraindicated interaction.
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Résumé
Meropenem causes a rapid and marked fall in serum valproic acid concentrations, often within a day or two of starting. Levels can drop below the therapeutic range, resulting in breakthrough seizures, and the effect may persist for days to weeks after the carbapenem is stopped.
Ce que signifie cette interaction, en termes simples
Meropenem and Valproic acid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Meropenem belongs to Anti Bacterial; Valproic acid belongs to Central Nervous System.
Pourquoi elle survient
Carbapenems are thought to inhibit hydrolysis of valproate glucuronide back to valproate and may reduce its absorption and red cell uptake, lowering valproate concentrations.
Conduite à tenir
Avoid the combination and use a non-carbapenem antibiotic. If a carbapenem is unavoidable, add an alternative anticonvulsant, since increasing the valproate dose does not reliably overcome the effect.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Meropenem
Autres interactions de Valproic acid
- Ertapenem + Valproic acid Contre-indiquée
- Imipenem / cilastatin / relebactam + Valproic acid Contre-indiquée
- Imipenem / cilastatin + Valproic acid Contre-indiquée
- Meropenem / vaborbactam + Valproic acid Contre-indiquée
- Calcium / magnesium / potassium / sodium oxybates + Valproic acid Majeure
- Cilastatin-imipenem + Valproic acid Majeure
Questions fréquentes
Can I take Meropenem with Valproic acid?
MediHelp rates the interaction as contraindicated. Meropenem and Valproic acid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Meropenem causes a rapid and marked fall in serum valproic acid concentrations, often within a day or two of starting. Levels can drop below the therapeutic range, resulting in breakthrough seizures, and the effect may persist for days to weeks after the carbapenem is stopped.
How serious is the interaction between Meropenem and Valproic acid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-carbapenem antibiotic. If a carbapenem is unavoidable, add an alternative anticonvulsant, since increasing the valproate dose does not reliably overcome the effect.
What other medicines interact with Meropenem?
MediHelp also lists interactions of Meropenem with, for example, Typhoid vaccine live, Amifampridine, Cholera vaccine. The full list is on the Meropenem page.
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