Interactions médicamenteuses
Amifampridine + Meropenem
Gravité: Modérée
Amifampridine and Meropenem: moderate interaction.
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Résumé
Both drugs can lower the seizure threshold, and carbapenems such as meropenem have been associated with seizures, particularly in renal impairment or CNS disease. Combining them may raise the risk of seizures in patients taking amifampridine.
Ce que signifie cette interaction, en termes simples
Amifampridine and Meropenem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amifampridine belongs to Central Nervous System; Meropenem belongs to Anti Bacterial.
Pourquoi elle survient
Additive pharmacodynamic lowering of the seizure threshold.
Conduite à tenir
Consider an alternative antibiotic with lower seizure liability in patients with a seizure history or renal impairment. If combined, adjust meropenem for renal function and monitor for neurological signs.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Meropenem
- Meropenem + Valproic acid Contre-indiquée
- Meropenem + Typhoid vaccine live Majeure
- Cholera vaccine + Meropenem Modérée
- Meropenem + Microbiota Modérée
- Meropenem + Probenecid Modérée
- Meropenem + Sodium picosulfate / magnesium oxide / anhydrous citric acid Modérée
Autres interactions de Amifampridine
- Amifampridine + Bupropion-naltrexone Majeure
- Amantadine + Amifampridine Modérée
- Amifampridine + Amitriptyline Modérée
- Amifampridine + Baclofen Modérée
- Amifampridine + Bethanechol Modérée
- Amifampridine + Bromocriptine Modérée
Questions fréquentes
Can I take Amifampridine with Meropenem?
MediHelp rates the interaction as moderate. Amifampridine and Meropenem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lower the seizure threshold, and carbapenems such as meropenem have been associated with seizures, particularly in renal impairment or CNS disease. Combining them may raise the risk of seizures in patients taking amifampridine.
How serious is the interaction between Amifampridine and Meropenem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antibiotic with lower seizure liability in patients with a seizure history or renal impairment. If combined, adjust meropenem for renal function and monitor for neurological signs.
What other medicines interact with Meropenem?
MediHelp also lists interactions of Meropenem with, for example, Valproic acid, Typhoid vaccine live, Cholera vaccine. The full list is on the Meropenem page.
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