Interactions médicamenteuses
Meropenem + Typhoid vaccine live
Gravité: Majeure
Meropenem and Typhoid vaccine live: major interaction.
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Résumé
Oral live typhoid vaccine depends on viable attenuated Salmonella Typhi in the gut. Meropenem is highly active against Salmonella and may reduce vaccine viability and the immune response.
Ce que signifie cette interaction, en termes simples
Meropenem and Typhoid vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pourquoi elle survient
Antibacterial activity inhibits the live attenuated Salmonella strain, reducing immunogenicity.
Conduite à tenir
Give live oral typhoid vaccine at least 3 days after the last meropenem dose, or vaccinate beforehand. Use the inactivated parenteral vaccine if timing cannot be separated.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Meropenem
- Meropenem + Valproic acid Contre-indiquée
- Amifampridine + Meropenem Modérée
- Cholera vaccine + Meropenem Modérée
- Meropenem + Microbiota Modérée
- Meropenem + Probenecid Modérée
- Meropenem + Sodium picosulfate / magnesium oxide / anhydrous citric acid Modérée
Questions fréquentes
Can I take Meropenem with Typhoid vaccine live?
MediHelp rates the interaction as major. Meropenem and Typhoid vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oral live typhoid vaccine depends on viable attenuated Salmonella Typhi in the gut. Meropenem is highly active against Salmonella and may reduce vaccine viability and the immune response.
How serious is the interaction between Meropenem and Typhoid vaccine live?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give live oral typhoid vaccine at least 3 days after the last meropenem dose, or vaccinate beforehand. Use the inactivated parenteral vaccine if timing cannot be separated.
What other medicines interact with Meropenem?
MediHelp also lists interactions of Meropenem with, for example, Valproic acid, Amifampridine, Cholera vaccine. The full list is on the Meropenem page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
