Interactions médicamenteuses
Mestranol + Tranexamic acid
Gravité: Contre-indiquée
Mestranol and Tranexamic acid: contraindicated interaction.
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Résumé
Oral tranexamic acid is antifibrinolytic and mestranol, a prodrug of ethinylestradiol, is prothrombotic. Together they raise the risk of venous and arterial thrombosis, and oral tranexamic acid labeling contraindicates use with combined hormonal contraceptives.
Ce que signifie cette interaction, en termes simples
Mestranol and Tranexamic acid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Additive prothrombotic effects of fibrinolysis inhibition and estrogen-induced increases in clotting factors.
Conduite à tenir
Avoid the combination; use non-hormonal or progestin-only contraception while taking tranexamic acid, or choose another heavy-bleeding treatment.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Tranexamic acid
- Dienogest / estradiol valerate + Tranexamic acid Contre-indiquée
- Ethinyl estradiol-drospirenone + Tranexamic acid Contre-indiquée
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contre-indiquée
- Ethinyl estradiol-norgestimate + Tranexamic acid Contre-indiquée
- Ethinylestradiol + Tranexamic acid Contre-indiquée
- Alteplase + Tranexamic acid Majeure
Questions fréquentes
Can I take Mestranol with Tranexamic acid?
MediHelp rates the interaction as contraindicated. Mestranol and Tranexamic acid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Oral tranexamic acid is antifibrinolytic and mestranol, a prodrug of ethinylestradiol, is prothrombotic. Together they raise the risk of venous and arterial thrombosis, and oral tranexamic acid labeling contraindicates use with combined hormonal contraceptives.
How serious is the interaction between Mestranol and Tranexamic acid?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use non-hormonal or progestin-only contraception while taking tranexamic acid, or choose another heavy-bleeding treatment.
What other medicines interact with Tranexamic acid?
MediHelp also lists interactions of Tranexamic acid with, for example, Dienogest / estradiol valerate, Ethinyl estradiol-drospirenone, Ethinyl estradiol-levonorgestrel. The full list is on the Tranexamic acid page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
