Interactions médicamenteuses
Metformin-pioglitazone + Trilaciclib
Gravité: Majeure
Metformin-pioglitazone and Trilaciclib: major interaction.
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Résumé
Trilaciclib inhibits OCT2, MATE1 and MATE-2K, reducing metformin renal clearance and increasing its concentrations. This raises the risk of lactic acidosis.
Ce que signifie cette interaction, en termes simples
Metformin-pioglitazone and Trilaciclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Metformin-pioglitazone belongs to Endocrine; Trilaciclib belongs to Oncology.
Pourquoi elle survient
Trilaciclib inhibits renal OCT2 and MATE transporters, decreasing metformin elimination.
Conduite à tenir
Avoid metformin around trilaciclib dosing as per labeling and monitor renal function and blood glucose.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Metformin-pioglitazone
Autres interactions de Trilaciclib
Questions fréquentes
Can I take Metformin-pioglitazone with Trilaciclib?
MediHelp rates the interaction as major. Metformin-pioglitazone and Trilaciclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trilaciclib inhibits OCT2, MATE1 and MATE-2K, reducing metformin renal clearance and increasing its concentrations. This raises the risk of lactic acidosis.
How serious is the interaction between Metformin-pioglitazone and Trilaciclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid metformin around trilaciclib dosing as per labeling and monitor renal function and blood glucose.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
