Interactions médicamenteuses
Canagliflozin-metformin + Trilaciclib
Gravité: Majeure
Canagliflozin-metformin and Trilaciclib: major interaction.
Dernière mise à jour
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Résumé
Trilaciclib inhibits OCT2, MATE1 and MATE2-K, which mediate renal secretion of metformin, and is expected to increase metformin exposure rather than decrease it. This raises the risk of metformin accumulation and lactic acidosis.
Ce que signifie cette interaction, en termes simples
Canagliflozin-metformin and Trilaciclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Canagliflozin-metformin belongs to Endocrine; Trilaciclib belongs to Oncology.
Pourquoi elle survient
Inhibition of renal OCT2 and MATE1/MATE2-K transporters reduces metformin elimination.
Conduite à tenir
Hold metformin on the day of trilaciclib infusion or use an alternative antidiabetic agent where possible. If continued, monitor renal function and for signs of lactic acidosis.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Canagliflozin-metformin
Autres interactions de Trilaciclib
- Alogliptin-metformin + Trilaciclib Majeure
- Cisplatin + Trilaciclib Majeure
- Dalfampridine + Trilaciclib Majeure
- Dapagliflozin-metformin + Trilaciclib Majeure
- Empagliflozin-metformin + Trilaciclib Majeure
- Glyburide-metformin + Trilaciclib Majeure
Questions fréquentes
Can I take Canagliflozin-metformin with Trilaciclib?
MediHelp rates the interaction as major. Canagliflozin-metformin and Trilaciclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trilaciclib inhibits OCT2, MATE1 and MATE2-K, which mediate renal secretion of metformin, and is expected to increase metformin exposure rather than decrease it. This raises the risk of metformin accumulation and lactic acidosis.
How serious is the interaction between Canagliflozin-metformin and Trilaciclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold metformin on the day of trilaciclib infusion or use an alternative antidiabetic agent where possible. If continued, monitor renal function and for signs of lactic acidosis.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
