Interactions médicamenteuses
Alogliptin-metformin + Trilaciclib
Gravité: Majeure
Alogliptin-metformin and Trilaciclib: major interaction.
Dernière mise à jour
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Résumé
Trilaciclib inhibits renal and hepatic cation transporters involved in metformin elimination, so metformin exposure is expected to rise rather than fall. Increased metformin concentrations raise the risk of metformin toxicity including lactic acidosis.
Ce que signifie cette interaction, en termes simples
Alogliptin-metformin and Trilaciclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Alogliptin-metformin belongs to Endocrine; Trilaciclib belongs to Oncology.
Pourquoi elle survient
Trilaciclib inhibits OCT2, MATE1 and MATE2-K, decreasing renal secretion of metformin.
Conduite à tenir
Metformin labeling advises avoiding this combination; hold metformin around trilaciclib infusion or choose an alternative antidiabetic. If unavoidable, monitor renal function, lactate-related symptoms and glycemic control.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Alogliptin-metformin
Autres interactions de Trilaciclib
Questions fréquentes
Can I take Alogliptin-metformin with Trilaciclib?
MediHelp rates the interaction as major. Alogliptin-metformin and Trilaciclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trilaciclib inhibits renal and hepatic cation transporters involved in metformin elimination, so metformin exposure is expected to rise rather than fall. Increased metformin concentrations raise the risk of metformin toxicity including lactic acidosis.
How serious is the interaction between Alogliptin-metformin and Trilaciclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Metformin labeling advises avoiding this combination; hold metformin around trilaciclib infusion or choose an alternative antidiabetic. If unavoidable, monitor renal function, lactate-related symptoms and glycemic control.
What other medicines interact with Alogliptin-metformin?
MediHelp also lists interactions of Alogliptin-metformin with, for example, Clozapine, Contrast media, Diatrizoate. The full list is on the Alogliptin-metformin page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
