Interactions médicamenteuses
Cisplatin + Trilaciclib
Gravité: Majeure
Cisplatin and Trilaciclib: major interaction.
Dernière mise à jour
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Résumé
Trilaciclib inhibits renal transporters involved in cisplatin uptake and secretion, which may alter cisplatin accumulation in the kidney. This could increase the risk of dose-related nephrotoxicity.
Ce que signifie cette interaction, en termes simples
Cisplatin and Trilaciclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cisplatin belongs to Oncology; Trilaciclib belongs to Oncology.
Pourquoi elle survient
Inhibition of OCT2, MATE1 and MATE2-K by trilaciclib changes renal tubular transport of cisplatin.
Conduite à tenir
Avoid using trilaciclib with cisplatin-containing regimens, as labeling advises. If combined, monitor serum creatinine and electrolytes closely.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Cisplatin
- Cidofovir + Cisplatin Contre-indiquée
- Adefovir + Cisplatin Majeure
- Adenovirus types 4 and 7 live + Cisplatin Majeure
- Amikacin + Cisplatin Majeure
- Amphotericin b deoxycholate + Cisplatin Majeure
- Amphotericin b + Cisplatin Majeure
Autres interactions de Trilaciclib
Questions fréquentes
Can I take Cisplatin with Trilaciclib?
MediHelp rates the interaction as major. Cisplatin and Trilaciclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Trilaciclib inhibits renal transporters involved in cisplatin uptake and secretion, which may alter cisplatin accumulation in the kidney. This could increase the risk of dose-related nephrotoxicity.
How serious is the interaction between Cisplatin and Trilaciclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using trilaciclib with cisplatin-containing regimens, as labeling advises. If combined, monitor serum creatinine and electrolytes closely.
What other medicines interact with Cisplatin?
MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
